The initial association "Tübinger Offensive Stadtmission" was founded in 1987 by Jobst and Charlotte Bittner as a result of a prayer fellowship with other married couples. After three years of interdenominational services, they started an independant free church in 1990, which is today known as the "TOS ChurchTübingen". Since 1997, numerous congregations and ministries have been established in twelve nations, including houses for street children in South America, rehabilitation centers for drug addicts in Eastern Europe, and prayer centers.

In Germany, congregations and social ministries have been established in Leipzig, Ueckermünde, Albstadt-Tailfingen and Halle.

Through a dedicated prayer ministry, 24/7 prayer centers have been established in various cities in Europe as well as in North and South America.

TOS Ministries International  works as part of TOS Ministries among street children, drug addicts and the needy, who are changed and empowered by the love of God to transform their societies. 

In 2007, the first  March of Life was held. Within 10 years, the first March of Life from Bisingen to Dachau in 2007 grew into a worldwide movement that was honored by the Israeli Knesset in 2011 and 2015. March of Life has been an independent association since 2015.